I did some testing on both 32bit and 64bit.
Playonlinux 32bit needs to have wxPython version 126.96.36.199 put into the slack-required file. As the dependencies are still satisfied with wxPython 188.8.131.52 but it will not work with that.
However, after installing wxPython I was able to install and run a couple applications.
Playonlinux 64bit complains about missing 32bit openGL and says there may be problems.
Tried a couple things, I can't get anything to run in 64bit.
Error in POL_Wine
Wine seems to have crashed.